Modeling gene regulatory network rewiring to understand complex phenotypes

SemIDEEV
 20/03/2026
 12:00:00
 Mariike Kuijjer, University of Helsinki, Finland
 IDEEV - Salle Rosalind Franklin

Gene regulatory networks govern how cells translate genomic information into complex phenotypes. Most network modeling approaches estimate condition-specific “aggregate” networks, masking regulatory heterogeneity across individuals and cell types. In this talk, I will present computational frameworks that integrate multi-omics data to progressively refine regulatory network inference, from condition-level models to individual-sample and cell-type–specific networks. Using examples ranging from tissue-specific regulation to cancer progression, I will illustrate how modeling regulatory rewiring reveals mechanisms underlying phenotypic diversity across biological contexts.