Evolution and genomes

 03/07/2021 -  EGCE
The team “Evolution and genomes” is interested in the evolution of the structure and function of genomes, at the organisms or populations or species scale.

Co leaders :
Nicolas Pollet (CNRS) Aurélie Hua-Van (UPSay)


Dynamics and evolution of the genomes: Impact of selfish genes (Transposable elements, meiotic distorter) and polyploidization. Interactions within genomes, especially at the scale of gene networks which are part of phenotype realisation or help developmental or physiological or of the cellular cycle processes to be set up. Genetic and epigenetic factors in evolution and adaptation.


Compared biology, Genomics, Population genetics, Theoretical biology. All use the tools of molecular biology and of bio-informatics, and lead to the making of scripts and specific tools for research/sequence analysis (molecular evolution, phylogeny) and for high throuput data treatment.



  • Filée J. , Becker HF., Mellottee L., Eddine RZ., Li Z., Yin W., Lambry JC., Liebl U., Myllykallio H.. (2023) Bacterial origins of thymidylate metabolism in Asgard archaea and Eukarya. Nat Commun, 1 (14) 838
  • Burban E., Tenaillon MI., Le Rouzic A. , Tellier A.. (2022) Gene network simulations provide testable predictions for the molecular domestication syndrome. Genetics, 2 (220) iyab214
  • Chevin LM., Leung C., Le Rouzic A. , Uller T.. (2022) Using phenotypic plasticity to understand the structure and evolution of the genotype–phenotype map. Genetica, 3-4 (150) 209-221
  • Le Rouzic A. . (2022) Gene network robustness as a multivariate character. Peer Community Journal, (2) e26
  • David O., Le Rouzic A. , Dillmann C.. (2021) Optimization of sampling designs for pedigrees and association studies. Biometrics,
  • Desbiez-Piat A., Le Rouzic A. , Tenaillon MI., Dillmann C.. (2021) Interplay between extreme drift and selection intensities favors the fixation of beneficial mutations in selfing maize populations. Genetics, 2 (219)
  • Devilliers M., Garrido D., Poidevin M., Rubin T., Le Rouzic A. , Montagne J., Andrew D.. (2021) Differential metabolic sensitivity of insulin-like-response- and TORC1-dependent overgrowth in Drosophila fat cells. Genetics, 1 (217) iyaa010
  • Gauthier J., Boulain H., van Vugt JJFA., Baudry L., Persyn E., Aury JM., Noel B., Bretaudeau A., Legeai F., Warris S., Chebbi MA., Dubreuil G., Duvic B., Kremer N., Gayral P., Musset K., Josse T., Bigot D., Bressac C., Moreau S., Periquet G., Harry M., Montagné N., Boulogne I., Sabeti-Azad M., Maïbèche M., Chertemps T., Hilliou F., Siaussat D., Amselem J., Luyten I., Capdevielle-Dulac C., Labadie K., Merlin BL., Barbe V., de Boer JG., Marbouty M., Cônsoli FL., Dupas S., Hua-Van A. , Le Goff G., Bézier A., Jacquin-Joly E., Whitfield JB., Vet LEM., Smid HM., Kaiser L., Koszul R., Huguet E., Herniou EA., Drezen JM.. (2021) Chromosomal scale assembly of parasitic wasp genome reveals symbiotic virus colonization. Commun Biol, 1 (4) 104
  • Herpin A., Schartl M., Depincé A., Guiguen Y., Bobe J., Hua-Van A. , Hayman ES., Octavera A., Yoshizaki G., Nichols KM., Goetz GW., Luckenbach JA.. (2021) Allelic diversification after transposable element exaptation promoted gsdf as the master sex determining gene of sablefish. Genome Res., 8 (31) 1366-1380
  • Pélabon C., Albertsen E., Rouzic AL., Firmat C., Bolstad GH., Armbruster WS., Hansen TF.. (2021) Quantitative assessment of observed versus predicted responses to selection. Evolution, 9 (75) 2217-2236
  • Benoist R., Capdevielle‐Dulac C., Chantre C., Jeannette R., Calatayud PA., Drezen JM., Dupas S., Le Rouzic A. , Le Ru B., Moreau L., Van Dijk E., Kaiser L., Mougel F.. (2020) Quantitative Trait Loci involved in the reproductive success of a parasitoid wasp. Mol Ecol, mec.15567
  • Jallet AJ., Le Rouzic A. , Genissel A.. (2020) Evolution and Plasticity of the Transcriptome Under Temperature Fluctuations in the Fungal Plant Pathogen Zymoseptoria tritici. Front. Microbiol., (11) 573829
  • Le Rouzic A. , Renneville C., Millot A., Agostini S., Carmignac D., Édeline Éric.. (2020) Unidirectional response to bidirectional selection on body size II. Quantitative genetics. Ecology and Evolution, 20 (10) 11453-11466
  • Renneville C., Millot A., Agostini S., Carmignac D., Maugars G., Dufour S., Le Rouzic A. , Edeline E.. (2020) Unidirectional response to bidirectional selection on body size. I. Phenotypic, life‐history, and endocrine responses. Ecol Evol, 19 (10) 10571-10592
  • Saint-Leandre B., Capy P., Hua-Van A. , Filée J. , Gonzalez J.. (2020) piRNA and Transposon Dynamics in Drosophila: A Female Story. Genome Biology and Evolution, 6 (12) 931-947
  • Debat V., Le Rouzic A. . (2019) Canalization, a central concept in biology. Seminars in Cell & Developmental Biology, (88) 1-3
  • Schneider DI., Ehrman L., Engl T., Kaltenpoth M., Hua-Van A. , Le Rouzic A. , Miller WJ.. (2019) Symbiont-Driven Male Mating Success in the Neotropical Drosophila paulistorum Superspecies. Behav Genet, 1 (49) 83-98
  • Odorico A., Rünneburger E., Le Rouzic A. . (2018) Modelling the influence of parental effects on gene‐network evolution. J. Evol. Biol., 5 (31) 687-700
  • Bouallègue M., Rouault JD., Hua-Van A. , Makni M., Capy P.. (2017) Molecular Evolution of piggyBac Superfamily: From Selfishness to Domestication. Genome Biol Evol, 2 (9) 323-339
  • Denis B., Claisse G., Le Rouzic A. , Wicker-Thomas C., Lepennetier G., Joly D.. (2017) Male accessory gland proteins affect differentially female sexual receptivity and remating in closely related Drosophila species. Journal of Insect Physiology, (99) 67-77
  • Saint-Leandre B., Clavereau I. , Hua-Van A. , Capy P.. (2017) Transcriptional polymorphism of pi RNA regulatory genes underlies the mariner activity in Drosophila simulans testes. Mol Ecol, 14 (26) 3715-3731
  • Helleu Q., Gérard P., Dubruille R., Ogereau D. , Prud'homme B., Loppin B., Montchamp-Moreau C. . (2016) Rapid evolution of a Y-chromosome heterochromatin protein underlies sex chromosome meiotic drive. Proceedings of the National Academy of Sciences of the United States of America, 15 (113) 4110 - 4115
  • Le Rouzic A. , Álvarez-Castro JM.. (2016) Epistasis-Induced Evolutionary Plateaus in Selection Responses. The American Naturalist, 6 (188) E134-E150
  • Renneville C., Rouzic AL., Baylac M., Millot A., Loisel S., Edeline E.. (2016) Morphological drivers of trophic cascades. Oikos, 8 (125) 1193-1202
  • Robillard E. , Le Rouzic A. , Zhang Z., Capy P., Hua-Van A. . (2016) Experimental evolution reveals hyperparasitic interactions among transposable elements. Proc. Natl. Acad. Sci. U.S.A., 51 (113) 14763-14768
  • Rünneburger E., Le Rouzic A. . (2016) Why and how genetic canalization evolves in gene regulatory networks. BMC Evol Biol, 1 (16) 239
  • Wallau GL., Capy P., Loreto E., Le Rouzic A. , Hua-Van A. . (2016) VHICA, a New Method to Discriminate between Vertical and Horizontal Transposon Transfer: Application to the Mariner Family within Drosophila. Mol Biol Evol, 4 (33) 1094-1109
  • Filée J. , Rouault JD., Harry M., Hua-Van A. . (2015) Mariner transposons are sailing in the genome of the blood-sucking bug Rhodnius prolixus. BMC Genomics, (16) 1061
  • Gasmi L., Boulain H., Gauthier J., Hua-Van A. , Musset K., Jakubowska AK., Aury JM., Volkoff AN., Huguet E., Herrero S., Drezen JM.. (2015) Recurrent Domestication by Lepidoptera of Genes from Their Parasites Mediated by Bracoviruses. PLoS Genet, 9 (11) e1005470
  • Hoen DR., Hickey G., Bourque G., Casacuberta J., Cordaux R., Feschotte C., Fiston-Lavier AS., Hua-Van A. , Hubley R., Kapusta A., Lerat E., Maumus F., Pollock DD., Quesneville H., Smit A., Wheeler TJ., Bureau TE., Blanchette M.. (2015) A call for benchmarking transposable element annotation methods. Mobile DNA, 1 (6) 13