Dominique DE VIENNE

Dominique DE VIENNE

 last updated 18/09/2023 -   +33 (0)1 69 33 23 60
+33 (0)6 77 79 94 31
 Biology and Adaptation, Systems in Evolution
 UPSay, Professor
 publications - orcid 


  • Professor emeritus at the University Paris-Saclay (2017–)
  • Professor at the University Paris-Sud (1990–2017).
  • Former Research Director at the French National Institute of Agronomical Research (INRA).

Research management

  • Former Director of the Plant Genetics Laboratory (INRA, Université Paris-Sud, CNRS, AgroParisTech) in Gif-sur-Yvette (1999–2014)
  • Member of the Scientific Council of the Doctoral Schools Genes, Genomes, Cells, then Structure and Dynamics of the Living Systems of the Université Paris-Saclay (2000–2022).
  • Regular member of scientist evaluation authorities (Université Paris-Sud, CNRS and INRA) and of the French High Council for Evaluation of Research and Higher Education (Hcéres).

Research interests

My general scientific interest is focused on the relationships between genotype and phenotype and between phenotypic levels. My work dealt initially with the analysis of maize responses to water deficit, using molecular markers and proteomics. My group played a pioneer role in quantitative proteomics and in the detection of genes that control protein expression (Protein Quantity Loci, known as PQLs or pQTLs).

My current research area is modeling in quantitative genetic, based on the MCA (Metabolic Control Analysis) and systems biology. In this context, I have analyzed the basis of heterosis (hybrid vigor), a major phenomenon in plant and animal breeding, as well as the evolution of enzyme concentrations under selection for high metabolic flux.


  • Genetics and Quantitative genetics
  • Eukaryote Evolution
  • Metabolic Control Analysis.


  • Coton C., Dillmann C., de Vienne D. . (2023) Evolution of enzyme levels in metabolic pathways: A theoretical approach. Part 2. Journal of Theoretical Biology, (558) 111354
  • Coton C., Talbot G., Le Louarn M., Dillmann C., de Vienne D. . (2022) Evolution of enzyme levels in metabolic pathways: A theoretical approach. Part 1. Journal of Theoretical Biology, (538) 111015
  • de Vienne D. , Capy P.. (2022) Special issue on “The relationship between genotype and phenotype: new insight into an old question”. Genetica, 3-4 (150) 151-151
  • de Vienne D. . (2022) What is a phenotype? History and new developments of the concept. Genetica, 3-4 (150) 153-158
  • Petrizzelli MS., de Vienne D. , Nidelet T., Noûs C., Dillmann C., Kaleta C.. (2021) Data integration uncovers the metabolic bases of phenotypic variation in yeast. PLoS Comput Biol, 7 (17) e1009157
  • de Vienne D. , Fiévet JB.. (2020) The Pitfalls of Heterosis Coefficients. Plants, 7 (9) 875
  • Petrizzelli M., de Vienne D. , Dillmann C.. (2019) Decoupling the Variances of Heterosis and Inbreeding Effects Is Evidenced in Yeast's Life-History and Proteomic Traits. Genetics, 2 (211) 741-756
  • Petrizzelli M., 8 juillet 2019, Mathematical modelling and integration of complex biological data: analysis of the heterosis phenomenon in yeas, PhD Thesis, Université Paris-Saclay
  • Vasseur F., Fouqueau L., de Vienne D. , Nidelet T., Violle C., Weigel D.. (2019) Nonlinear phenotypic variation uncovers the emergence of heterosis in Arabidopsis thaliana. PLoS Biol, 4 (17) e3000214
  • Fiévet JB., Nidelet T., Dillmann C., de Vienne D. . (2018) Heterosis Is a Systemic Property Emerging From Non-linear Genotype-Phenotype Relationships: Evidence From in Vitro Genetics and Computer Simulations. Front. Genet., (9)
  • Sabarly V., Aubron C., Glodt J., Balliau T., Langella O., Chevret D., Rigal O., Bourgais A., Picard B., de Vienne D. , Denamur E., Bouvet O., Dillmann C.. (2016) Interactions between genotype and environment drive the metabolic phenotype within Escherichia coli isolates. Environmental microbiology, 1 (18) 100-17