Positions

• Professor emeritus at the University Paris-Saclay (2017–)
• Professor at the University Paris-Sud (1990–2017).
• Former Research Director at the French National Institute of Agronomical Research (INRA).

Research management

• Former Director of the Plant Genetics Laboratory (INRA, Université Paris-Sud, CNRS, AgroParisTech) in Gif-sur-Yvette (1999–2014)
• Member of the Scientific Council of the Doctoral Schools Genes, Genomes, Cells, then Structure and Dynamics of the Living Systems of the Université Paris-Saclay (2000–2022).
• Regular member of scientist evaluation authorities (Université Paris-Sud, CNRS and INRA) and of the French High Council for Evaluation of Research and Higher Education (Hcéres).

Research interests

The question underlying all my research is that of the relationship between genotypic variation and phenotypic variation, at various levels of biological organization. My early work focused on the response of maize to water deficit, using molecular merkers and quantitative proteomics. My team played a pioneering role in this field, showing how to map the genes that control protein abundances (Protein Quantity Loci, or pQTL). My current research focuses on the modeling of quantitative variation, using a systems biology approach based in particular on MCA (Metabolic Control Analysis). In this context, I have analyzed: (1) the basis of heterosis, a major phenomenon in animal and plant breeding, (2) the evolution of enzyme concentrations when there is directional selection on metabolic fluxes, (3) the genetic consequences of the non-linearity of the relationship between the genotype and the successive phenotypic levels.

Teaching

• Genetics and Quantitative genetics
• Eukaryote Evolution
• Metabolic Control Analysis.

Publications

2023

• Coton C., Dillmann C., de Vienne D. . (2023) Evolution of enzyme levels in metabolic pathways: A theoretical approach. Part 2. Journal of Theoretical Biology, (558) 111354

2022

• Coton C., Talbot G., Le Louarn M., Dillmann C., de Vienne D. . (2022) Evolution of enzyme levels in metabolic pathways: A theoretical approach. Part 1. Journal of Theoretical Biology, (538) 111015
• de Vienne D. , Capy P.. (2022) Special issue on “The relationship between genotype and phenotype: new insight into an old question”. Genetica, 3-4 (150) 151-151
• de Vienne D. . (2022) What is a phenotype? History and new developments of the concept. Genetica, 3-4 (150) 153-158

2021

• Petrizzelli MS., de Vienne D. , Nidelet T., Noûs C., Dillmann C., Kaleta C.. (2021) Data integration uncovers the metabolic bases of phenotypic variation in yeast. PLoS Comput Biol, 7 (17) e1009157

2020

• de Vienne D. , Fiévet JB.. (2020) The Pitfalls of Heterosis Coefficients. Plants, 7 (9) 875

2019

• Petrizzelli M., de Vienne D. , Dillmann C.. (2019) Decoupling the Variances of Heterosis and Inbreeding Effects Is Evidenced in Yeast's Life-History and Proteomic Traits. Genetics, 2 (211) 741-756
• Petrizzelli M., 8 juillet 2019, Mathematical modelling and integration of complex biological data: analysis of the heterosis phenomenon in yeas, PhD Thesis, Université Paris-Saclay
• Vasseur F., Fouqueau L., de Vienne D. , Nidelet T., Violle C., Weigel D.. (2019) Nonlinear phenotypic variation uncovers the emergence of heterosis in Arabidopsis thaliana. PLoS Biol, 4 (17) e3000214

2018

• Fiévet JB., Nidelet T., Dillmann C., de Vienne D. . (2018) Heterosis Is a Systemic Property Emerging From Non-linear Genotype-Phenotype Relationships: Evidence From in Vitro Genetics and Computer Simulations. Front. Genet., (9)

2016

• Sabarly V., Aubron C., Glodt J., Balliau T., Langella O., Chevret D., Rigal O., Bourgais A., Picard B., de Vienne D. , Denamur E., Bouvet O., Dillmann C.. (2016) Interactions between genotype and environment drive the metabolic phenotype within Escherichia coli isolates. Environmental microbiology, 1 (18) 100-17

2013

• Albertin W., Marullo P., Bely M., Aigle M., Bourgais A., Langella O., Balliau T., Chevret D., Valot B., da Silva T., Dillmann C., de Vienne D. , Sicard D.. (2013) Linking post-translational modifications and variation of phenotypic traits. Molecular & cellular proteomics : MCP, 3 (12) 720-35
• Albertin W., da Silva T., Rigoulet M., Salin B., Masneuf-Pomarede I., de Vienne D. , Sicard D., Bely M., Marullo P.. (2013) The mitochondrial genome impacts respiration but not fermentation in interspecific Saccharomyces hybrids. PloS one, 9 (8) e75121
• Blein-Nicolas M., Albertin W., Valot B., Marullo P., Sicard D., Giraud C., Huet S., Bourgais A., Dillmann C., de Vienne D. , Zivy M.. (2013) Yeast proteome variations reveal different adaptive responses to grape must fermentation. Molecular biology and evolution, 6 (30) 1368-83