Dominique DE VIENNE

Dominique DE VIENNE

 dernières mises à jour 03/04/2023 -   01 69 33 23 60
06 77 79 94 31
 Biologie de l'Adaptation et Systèmes en Évolution
 UPSay, Professeur
 publications - orcid 


  • Professor at the Université Paris-Sud since 1990.
  • Former Research Director at the French National Institute of Agronomical Research (INRA).

Research management

  • Former Director of the Plant Genetics Laboratory (INRA, Université Paris-Sud, CNRS, AgroParisTech) in Gif-sur-Yvette (1999–2014)
  • Member of the Scientific Council of the Doctoral Schools Genes, Genomes, Cells, then Structure and Dynamics of the Living Systems of the Université Paris-Saclay (2000-present).
  • Regular member of scientist evaluation authorities (Université Paris-Sud, CNRS and INRA) and of the French High Council for Evaluation of Research and Higher Education (Hcéres).

Research interests

My constant scientific interest is focused on the relationships between genotype and phenotype and on the emergence phenomenon. My work dealt initially with the analysis of maize responses to water deficit, using molecular markers and proteomics. My group played a pioneer role in quantitative proteomics in France, and in the detection of genes that control protein expression (Protein Quantity Loci, or PQL). My current area of research is modelling in quantitative genetics, relying on biochemical theory of metabolic networks and systems biology. In this context I analyse the bases of heterosis (hybrid vigor), a major phenomenon for plant and animal breeding.


  • Quantitative and populations genetics
  • Eukaryote Evolution
  • Mathematic modelling of metabolism.


  • Coton C., Dillmann C., de Vienne D. . (2023) Evolution of enzyme levels in metabolic pathways: A theoretical approach. Part 2. Journal of Theoretical Biology, (558) 111354
  • Coton C., Talbot G., Le Louarn M., Dillmann C., de Vienne D. . (2022) Evolution of enzyme levels in metabolic pathways: A theoretical approach. Part 1. Journal of Theoretical Biology, (538) 111015
  • de Vienne D. , Capy P.. (2022) Special issue on “The relationship between genotype and phenotype: new insight into an old question”. Genetica, 3-4 (150) 151-151
  • de Vienne D. . (2022) What is a phenotype? History and new developments of the concept. Genetica, 3-4 (150) 153-158
  • Petrizzelli MS., de Vienne D. , Nidelet T., Noûs C., Dillmann C., Kaleta C.. (2021) Data integration uncovers the metabolic bases of phenotypic variation in yeast. PLoS Comput Biol, 7 (17) e1009157
  • de Vienne D. , Fiévet JB.. (2020) The Pitfalls of Heterosis Coefficients. Plants, 7 (9) 875
  • Petrizzelli M., de Vienne D. , Dillmann C.. (2019) Decoupling the Variances of Heterosis and Inbreeding Effects Is Evidenced in Yeast's Life-History and Proteomic Traits. Genetics, 2 (211) 741-756
  • Petrizzelli M., 8 juillet 2019, Mathematical modelling and integration of complex biological data: analysis of the heterosis phenomenon in yeas, PhD Thesis, Université Paris-Saclay
  • Vasseur F., Fouqueau L., de Vienne D. , Nidelet T., Violle C., Weigel D.. (2019) Nonlinear phenotypic variation uncovers the emergence of heterosis in Arabidopsis thaliana. PLoS Biol, 4 (17) e3000214
  • Fiévet JB., Nidelet T., Dillmann C., de Vienne D. . (2018) Heterosis Is a Systemic Property Emerging From Non-linear Genotype-Phenotype Relationships: Evidence From in Vitro Genetics and Computer Simulations. Front. Genet., (9)
  • Sabarly V., Aubron C., Glodt J., Balliau T., Langella O., Chevret D., Rigal O., Bourgais A., Picard B., de Vienne D. , Denamur E., Bouvet O., Dillmann C.. (2016) Interactions between genotype and environment drive the metabolic phenotype within Escherichia coli isolates. Environmental microbiology, 1 (18) 100-17